The opening scene of The Second Best Hospital in the Galaxy sets the tone perfectly: Dr. Sleech (Stephanie Hsu), an alien surgeon with tentacles that double as surgical tools, attempts to calm a patient anxiety-eating parasite mid-binge. It’s a moment that encapsulates the show’s unique blend of absurdity, gross-out humor, and genuine pathos—a combination that makes this adult animated series stand out in the crowded sci-fi comedy landscape.

Created by Cirocco Dunlap and premiering on Prime Video in February 2024, The Second Best Hospital in the Galaxy is a science fiction medical comedy that draws inspiration from Dunlap’s personal struggles with anxiety. The show centers on two intergalactic surgeons and best friends, Drs. Sleech (Hsu) and Klak (Keke Palmer), as they navigate the challenges of treating bizarre alien ailments while managing their own personal lives.

One of the series’ standout strengths is its willingness to tackle complex themes through a lens of humor and fantasy. The show, for instance, explores anxiety in a creative way by introducing an alien parasite that feeds off stress hormones. This metaphorical approach allows the show to delve into mental health issues without becoming overly didactic.

The voice cast is a major highlight. Stephanie Hsu and Keke Palmer have excellent chemistry as the leads, balancing humor and heart in equal measure. Their dynamic feels authentic, making their friendship the emotional core of the series. Natasha Lyonne‘s Nurse Tup steals every scene she’s in, delivering dry wit with perfect comedic timing. Her performance is a masterclass in understated humor, adding depth to what could have been a one-dimensional character.

Kieran Culkin, Maya Rudolph, and Sam Smith also deliver memorable performances as supporting characters. Culkin’s Dr. Plowp brings a grounded energy to the otherwise outlandish setting, while Rudolph’s Dr. Vlam adds a layer of gravitas. Sam Smith’s Dr. Azel, though less prominent, provides some of the show’s most absurd and entertaining moments.

The animation by Titmouse, Inc. is another strong suit. The vibrant colors and fluid movements bring the show’s galaxy to life, creating a visually striking world that feels both familiar and alien. The design of the characters and their environments is detailed and imaginative, adding to the show’s unique aesthetic.

However, the series isn’t without its flaws. The episodic structure can feel disjointed at times, with some storylines wrapping up too neatly while others seem to peter out. This inconsistency in pacing and resolution can make the show feel uneven, particularly in its early episodes.

Additionally, while the humor is often hit, it occasionally misses the mark, relying on over-the-top gags that fall flat. Some jokes feel forced or repetitive, detracting from the overall enjoyment. The show’s attempt to balance heavy themes with lighthearted comedy doesn’t always succeed, leading to moments that feel tonally inconsistent.

The depiction of anxiety is both a strength and a weakness. On one hand, it’s refreshing to see mental health struggles portrayed in such a unique and imaginative way. On the other hand, some of the more heavy-handed moments can feel preachy or out of place amidst the comedy. The show walks a fine line between education and entertainment, and while it generally succeeds, there are times when it stumbles.

In terms of comparison, The Second Best Hospital in the Galaxy has been likened to Futurama for its blend of sci-fi and humor. However, where Futurama excelled in its satirical edge and consistent storytelling, this series sometimes struggles to find its footing. That being said, it carves out its own niche with its unique premise and strong performances.

The target audience for this show is clearly millennials, given its marketing and thematic focus. Fans of animated sci-fi comedies like Rick and Morty or Futurama will likely find something to enjoy here, particularly those who appreciate a mix of humor and heartfelt moments.

Despite its flaws, The Second Best Hospital in the Galaxy is a promising debut from Cirocco Dunlap. It’s a show that isn’t afraid to take risks, and while not every gamble pays off, there’s enough here to make it worth watching.